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Literature summary extracted from

  • Bharadwaj, A.G.; Rector, K.; Simpson, M.A.
    Inducible hyaluronan production reveals differential effects on prostate tumor cell growth and tumor angiogenesis (2007), J. Biol. Chem., 282, 20561-20572.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.4.1.212 medicine hyaluronan synthase 3 is the most dramatically up-regulated isozyme in metastatic prostate tumor cells Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.212 a plasmid encoding FLAG epitope-tagged HAS3 for transfection of human prostate tumor cells is constructed, Tet-inducible 22Rv1 cells are generated Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.212 UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan] Homo sapiens
-
 UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
-
 ?
2.4.1.212 UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan] Homo sapiens
-
 UDP + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.212 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.212 22Rv1 cell
-
 Homo sapiens
-
2.4.1.212 prostate cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.212 UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
-
 Homo sapiens UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
-
 ?
2.4.1.212 UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
-
 Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.212 Has3
-
 Homo sapiens
2.4.1.212 hyaluronan synthase
-
 Homo sapiens